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Medaka Mutants at the National Institute of Radiological Sciences, Chiba

by Ishikawa Y.
Medakafish as a model system for vertebrate developmental genetics.
BioEssays 22: 487-495 (2000).


Methods of Induction
and Mutant Names
Body Regions or
Functions in Which
Abnormalities Are
First Detected
Degree of
Cell Death
When
Phenotypes
Are Detectable
Earliest
Detectable
Stages
Viability#
ENU-Induced Mutants
bff (bubbly fin fold) fin fold no fry viable
bs (blood spot) blood circulation extensive early embryo lethal
fv (fifivo) neural tube restricted early embryo lethal
ge (gray eyes)* pigment epithelium of retina no late embryo sublethal
js (jaw spot) blood circulation extensive early embryo lethal
k (knocked down) motility no fry sublethal
ke (keten) entire body extensive early embryo lethal
kt (kinked trunk) trunk no fry sublethal
lwl (large white liver) liver no late embryo lethal
nc-3 (non-circulation-3)* blood circulation extensive early embryo lethal
nc-4 (non-circulation-4) blood circulation extensive early embryo lethal
nc-5 (non-circulation-5) blood circulation extensive early embryo lethal
nc-6 (non-circulation-6) blood circulation extensive early embryo lethal
nc-7 (non-circulation-7) blood circulation extensive early embryo lethal
nc-8 (non-circulation-8) blood circulation extensive early embryo lethal
ne (nenem) entire body extensive early embryo lethal
neo (nezumi otoko) neural tube extensive early embryo sublethal
ntt (no tail tip) tail restricted early embryo subletha
nv (no ventricles) entire body extensive early embryo lethal
qt (q taro) optic tectum restricted early embryo sublethal
st-1 (short tail-1) tail restricted fry viable
st-2 (short tail-2) tail restricted fry viable
tb (twisted brain)** neural rod no gastrula lethal
te (thin embryo) neural rod extensive neurula lethal
tm (tejima) entire body extensive early embryo lethal
tot (tiny optic tectum) optic tectum no early embryo sublethal
tt (twisted tail) tail no fry sublethal
wh (white) body colour no young fish viable
zr (zone of red) entire body extensive early embryo lethal
X-Ray-Induced Mutants
(Including Spontaneous Ones
from the Mutant Lines)
dot (dead optic tectum) optic tectum and tail tip extensive early embryo lethal
dub (dumbo) entire body extensive early embryo lethal
nc-1 (non-circulation-1)*** blood circulation extensive early embryo lethal
nc-2 (non-circulation-2) blood circulation extensive early embryo lethal
oi (opaque isthmus) rhombencephalic isthmus restricted early embryo lethal
q (quiet) motility no fry sublethal
tb-2 (twisted brain-2) neural rod almost no neurula lethal
ut (undone tail) tail restricted early embryo subletha
ut-2 (undone tail-2) tail restricted early embryo subletha
Spontaneous Mutants
of (oil globule fuse delay)**** oil droplet of egg no early morula viable
Oot (One-sided optic tectum) optic tectum no early embryo viable
For details, see Ishikawa and Hyodo-Taguchi (1995)*39, Ishikawa (1996)**40, Ishikawa and Hyodo-Taguchi (1997)***41, and Hyodo-Taguchi (1979)****64. Viability# of the mutants is represented as follows: viable, sublethal (death shortly after hatching), and lethal (death before hatching).